Coronavirus is acellular meaning it is not a cell and is just nucleic acid surrounded by protein, it does not have a plasma membrane, cytoplasm or ribosomes. It is transmitted when an infected person talks, sneezes or coughs, droplets carrying the virus may land on a surface. Once in contact the coronavirus will enter through a mucus-lined surface, the T Zone (the nose, eyes and mouth). The coronavirus will then attach spike “fusion” proteins to bind to its complementary receptor protein called ACE2 which stands for angiotensin-converting enzyme 2, this helps to regulate blood pressure and is on the surface of host cells. The virus will after set of chemical changes which will fuse the membranes around the cell and virus together. This will therefore allow coronavirus to inject its RNA. Coronavirus is not alive, so it cannot undergo cell division instead so it uses the lytic pathway, the machinery like a ribosome inside the host cell will then be used to translate the RNA and make it into protein in order to make new copies of the virus. In the process the cell will be destroyed as all the viruses made in the cell will cause the cell to burst. This will go on to effect other cells, repeating the process. ACE2 is mainly found on goblet cells and ciliated cells which are mainly located lining the upper respiratory system. So, when the virus infects it will cause inflammation and irritation in the airways stimulating dry coughs. Healthy people will be able to fight off the infection here and preventing it to spread further. If your immune system is no strong enough, the lower respiratory system will then be infected. With the virus invading the lungs and specifically the alveoli. The virus will attack the cells in the alveoli. This will result immune cells being sent to the alveoli which will cause them to build with fluid and swell. This will impact more alveolar cells causing them to die and slough off. This will fill the lungs with debris and fluid. Interrupting oxygen transfer in the body and causes alveoli to collapse. This is called (ARDS) Acute Respiratory Distress Syndrome. Which will result in difficulty in breathing. Specific proteins are released into the blood call and transported to the hypothalamus which will stimulate high temperature leading to fever. Due to an insufficient oxygen supply the person may witness organ failure. The coronavirus has mutated because there are so many copies being generated in the cells of this genetic information, the RNA will not replicate precisely every time therefore introducing mutations in the virus, changes in the code.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here